Biophysical Platform

Biophysical Platform
Development of various platforms for studying microtubule dynamics
Understanding kinesin mediated cargo (nanomaterial) transport and microtubule dynamics

Highlight of recent progress in these areas as follows:

  • Development of various platforms for studying microtubule dynamics: We developed various platforms for studying nucleation of microtubule and dynamics using UV light illumination through photo-mask. These platforms are as follows: (a) biotin and Tris-NTA functionalised EM grid, (b) biotin micropatterned surface, (c) micropatterned surface with the presence of Tris-NTA and biotin functionality both in same micropattern as well as individual in adjacent micropattern.
    References: Biswas et al., Soft Matter, 2014; Saha et al., Chemical Communication, 2013; Jana et al., Macromol Biosci. 2013; Jana et al., RSC Adv. 2013; Saha et al., RSC Adv. 2013; Biswas et al., ChemBioChem, 2013.
  • Understanding kinesin mediated cargo (nanomaterial) transport and microtubule dynamics: In eukaryotic cell molecular motor proteins, especially kinesins plays important role in cellular functions such as mitosis, meiosis and transport of cellular cargo. Kinesin moves along the microtubule using ATP as energy source. Kinesin, which moves towards the plus-end and minus-end of the microtubule known as plus-end directed and minus-end directed kinesin respectively. We are interested to learn in details about the transport of molecules using kinesin as transporter and nanomaterials as cargo. In addition we are trying to understand microtubule dynamics using microtubule tip binding protein Mal3 using FRET.
    References: Mondal et al., Phys. Chem. Chem. Phys., 2015; Jana et al., Chemical Communication, 2014.
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